Creatine

Strong Evidence
Last reviewed July 2026

The most researched performance supplement on the planet. Safe, effective and widely underrated.

Overview

Creatine is a naturally occurring compound synthesised from glycine, arginine and methionine. It is stored primarily in muscle tissue as phosphocreatine, where it plays a central role in rapid ATP regeneration during short, intense exercise. With over 500 peer-reviewed studies to its name, creatine is the most researched dietary supplement in existence and consistently outperforms placebo for strength, power and muscle mass. It is also showing promise in emerging research for cognitive function.

Evidence rating

Strong Evidence

Evidence for creatine's effects on strength and high-intensity power output is exceptional — among the strongest of any supplement. Evidence for muscle mass gains is strong. The safety profile over decades of research is excellent. Concerns about kidney damage have not been borne out in people with healthy kidneys.

Common uses

  • Strong Evidence
    Increasing strength and power output
  • Strong Evidence
    Supporting muscle mass gains alongside resistance training
  • Strong Evidence
    Improving high-intensity and sprint performance
  • Moderate Evidence
    Supporting muscle recovery between sessions
  • Early Evidence
    Cognitive function support, especially under sleep deprivation

Safety & cautions

Worth checking with a pharmacist if you take medication.

Common forms

Creatine MonohydrateBest form

The gold standard. Cheapest, most studied, and equally effective to all other forms. Start here.

Micronised Creatine Monohydrate

Finer particles for better mixing. Same effectiveness at a slightly higher price.

Creatine HCl

More soluble, may cause less bloating. More expensive with no proven performance advantage.

Food sources

  • BeefApprox. 4-5g per 1kg raw
  • SalmonApprox. 4.5g per 1kg raw
  • HerringApprox. 6.5g per 1kg raw — richest fish source
Creatine — Evidence, Benefits & Buying Guide — The Herb Pusher